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KMID : 0358319960370091008
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Korean Journal of Urology
1996 Volume.37 No. 9 p.1008 ~ p.1014
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Verapamil Intralesional Injection for Peyronie's Disease
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Abstract
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Peyronie's disease is a distressing disorder that pathophysiology and therapeutic subset of this disease are fairly not established. We studied the effectiveness of verapamil for peyronie's disease which intralesionally injected with 10 mg
verapamil
every 2 weeks for 10 injections or more in 12 men among 15 men with Peyronie's disease at Pusan national University Hospital from May 1995 to May 1996. The mean age was 55.7 year-old (range 30-68). One case had failed prior steroid intralesional
injection and four cases had failed prior vitamin E oral medication. The mean volume of plaque was approximated with 7.5 MHz high frequency ultrasound at 3.7ml (range 0.1-8.4). The plaque causes the penile curvature which was discovered by
questioning
or intracavernosal injection of prostaglandin E1 in 9 cases (64.3%). Penile pain was rapidly resolved in all preeexisting 10 cases (100%). Of cases with the penile curvature on erection, angulation was decreased in 3 cases (33.3%). The penile
rigidity
on erection was inquired to be improved more or less in 4 cases (44.4%) with desirable sexual performance. Plaque volume and consistency were reduced in 6 cases (50%).
We concluded the verapamil intralesional injection is one of the effective nonboperative therapeutic modality for peyronie's disease because of the beneficial effects including complete pain relief, modest improvements in penile curvature and
erectile
function, decreased plaque volume and avoidance of disease progression without no adverse reactions.
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